Dr. Meller serves as graduate program director for Biomedical Informatics and also pursues several lines of research in molecular modeling, structural bioinformatics and computational genomics, at the intersection of data science and biomedicine.

Dr. Meller and his group have developed a number of successful methods for the prediction of protein structure, protein-protein interactions and functional hot spots in proteins. Several web servers developed by the group, including Sable, Sppider, Minnou and Polyview have widely been used, with a total of over 1 million submissions from more than 30,000 users in many countries.

Dr. Meller has also been active in the development and applications of methods for knowledge extraction from high dimensional genomic data. He and his group have been involved in many collaborative projects with direct medical relevance. Examples include identification of markers associated with disease subtypes in cancer and autoimmunity, modeling of signal transduction pathways in differentiation and development, and developing inhibitors of critical protein-protein interactions in autophagy, bone marrow transplants, and pathogen-host interactions.